当センターが共催いたします、第65回「生体機能の解明とその応用に関する研究会」が、5月30日（金）に、名古屋工業大学にて開催されます。
○日時：2025年5月30日（金） 13:30〜14:30
○場所：名古屋工業大学2号館2階0223室
〇主催：生体機能の解明とその応用に関する研究会
〇共催：名古屋工業大学 先端医用物理・情報工学研究センター
学術変革領域研究(B) しなやかさ生物学：生命はなぜ「しなやか」なのか？
〇講演者：Rosaire Mongrain（Professor, Department of Mechanical Engineering, McGill University）
〇タイトル：「Biomechanics of the Aortic root and Development of Digitial Twins for Surgical Interventions」
〇要旨：
Coronary artery disease is considered to be a major cause of mortality and morbidity in the developing world. It was shown that aortic root pathologies such as aortic stiffening and calcific aortic stenosis can contribute to the initiation and progression of this disease by affecting coronary blood flow. As a consequence the coronary blood flow and velocity profiles can be altered which could contribute to the development of coronary artery disease.
We present the evolution of a 3D Fluid Structure Interaction model of the aortic root incorporating the leaflet apparatus and the coronary structures down to the second bifurcations (small coronary arteries) that was developed over the years. This global model allows to assess to quantify the impact of several hemodynamic variables (aortic stiffening, viscoelasticity, hyper-elasticity) on the coronary perfusion.
We also present an initial strategy to develop a Digital Twin (DT) of the aortic root based on PINNs (Physics Informed Neural Networks) to provide physicians with a quasi-real time decision support tool for emergency surgical cases. The DT will also merge clinical pressure measurements (data driven) and the physics of the phenomena.
